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| CLINICAL STUDY OF OLFACTORY ENSHEATHING CELL TRANSPLANT FOR SPINAL CORD INJURY |
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| Research from China | |||
| Samstag, 24. Dezember 2005 um 10:30 Uhr | |||
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There are no translations available. Hong-Yun Huang Neurological Research and Treatment Center & Department of Neurosurgery, Beijing Xishan Hospital, Beijing 100041 China Objective: Pre-clinical studies have demonstrated that damaged axons of the Central Nervous System (CNS) can be repaired and regenerated with partial neurological functions recovery in the presence of some kind of environment. The aim of this study is to determine whether olfactory ensheathing cell (OEC) transplant can help patients with chronic spinal cord injury (SCI) which will be an impact for functional improvement. Methods: Aborted foetal olfactory bulbs were harvested and trypsinised down to single foetal OECs which were cultured for 12-17 days before being ready for use. There are 300 patients consisting of 222 complete SCI cases and 78 incomplete SCI cases. The foetal OECs were transplanted by injection into the spinal cord at opposing ends of the injury site. All patients were assessed before the transplantation and followed up to 2-8 weeks after the treatment according to ASIA standard. The different impacts such as: age, time after injury, gender, injury degree and injury level were compared for functional improvement after foetal OEC transplantation. Results: Neurological function partially improved according to ASIA standard, which were reflected by the increased motor scores , light touch scores and pin prick scores. There was no significant difference in functional improvement in motor, light touch and pin brick by comparison with different ages, operation times after injury, genders and injury degrees. For the injury levels, the increased motor scores and light touch scores are higher for the cervical level patients than for the thoracic level patients. Conclusion: Foetal OEC transplantation can fast improve partial neurological functions for chronic SCI. Factors such as age, time after injury, gender, and degree of injury than thoracic level had no impact on the functional improvement with foetal OEC transplantation, except for the injury level for which the increased motor scores and light touch scores were higher in cervical level group than in thoracic level group.
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