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| Agilent Publishes Stem Cell Discovery in China Collaboration |
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| IPS | |
| Mittwoch, 01. April 2009 um 16:54 Uhr | |
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There are no translations available. Source: Seeking Alpha In a collaboration, Agilent Technologies Inc. (NYSE: A), together with a team from the Shanghai Institutes for Biological Sciences and Tongi University, discovered new insight into how adult cells can be coaxed into a pluripotent state where they act like embryonic stem cells (ESC). Pluripotent stem cells have the ability to grow into all types of tissue. The researchers observed a developmental signaling network of 16 signaling pathways, including nine that had not previously been assigned roles in maintaining or inducing pluripotency. The findings of the collaboration’s research were published as "Yamanaka factors critically regulate the developmental signaling network in mouse embryonic stem cells" in the journal Cell Research. Discovered in 2006, the ability of adult stem cells to attain pluripotency creates an alternative to embryonic stem cells, which have the ability naturally. The study used Agilent chromatin immunoprecipitation-on-chip (ChIP-on-chip) and gene expression microarrays to study molecules known as "Yamanaka factors" and their roles in inducing pluripotency in mouse cells. Agilent provided the microarray kits under a 2008 Agilent grant. ChIP-on-chip microarrays are used to observe activity at "promoter regions" on the genome, where chemical events activate and deactivate various genes to control cellular functioning.
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| Zuletzt aktualisiert am Freitag, 03. April 2009 um 15:02 Uhr |