Dr. Cao Yongping - First Hospital of Peking University

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Wednesday, 07 December 2005 05:27

Presentation on Cartilage Repair

Name: Cao Yongping

Gender: Male

Nationality: Chinese

Address:

Department of Orthopedic Surgery
First Hospital of Peking University
Beijing, 100034, P. R. China

Summary:

Associate professor of Peking University. PhD in biomedical engineering graduated from Kagawa University of Japan. Clinical work specializes in treatment of bone joint disorders (mainly adult joint arthroplasty, cartilage repair with 3-D cultured chondrocyte or mesenchymal stem cell, ACL or PCL reconstruction). Research specializes bone biology, metabolism of bone and cartilage, tissue engineering of bone and cartilage, osteoporosis, and aseptic loosening of artificial prosthesis after total hip or knee arthroplasty. Acts on the Committee and member of many academic societies. Published many papers in English and in Chinese.

Academic Societies

- Committee of Chinese Association of Osteoporosis
- Committee of Chinese Osteoporosis Foundation
- Committee of Beijing Association of Osteoporosis
- Active member of International Chinese Hard Tissue Society
- Active Member of Japanese Society for Bone and Mineral Research
- Active Member of Japanese Society of Bone Morphometry
- Active Member of Japanese Society of osteoporosis
- Active Member of Chinese Society of Orthopedic Surgery
- Active Member of Chinese Society of Artificial Joint
- Active Member of Chinese Society of Biomaterials

Journal Editor:

- Editor for "Journal of Chinese Osteoporosis"
- Editor for "Journal of Chinese Bone and Mineral Research"
- Editor for "Journal of Chinese Medicine (English Version)"

Education:

2000.10—2004: Ph.D , Department of Orthopedic Surgery, Kagawa Medical University, Japan.

1991.7-1994.8: Masters, Postgraduate Institute of Health Center, Peking University, China

1985.9-1990.7: Bachelor, Binzhou Medical University, China.

Affiliations:

2004—now: Associate professor, Department of Orthopedic Surgery, First Hospital of Peking University, China.

1995.9-2000.9: Lecturer and Attending Doctor, Department of Orthopedic Surgery, First Hospital of Peking University, China.

1994.7-1995.8: Chief Residency, Department of Orthopedic Surgery, First Hospital of Peking University, China.

1990.9-1994.9: Residency, Department of Orthopedic Surgery, First Hospital of Peking University, China.

Clinical Focus:

1. Treatment of bone joint disorders, such as:

    A: Joint arthroplasty in hip, knee, elbow, and ankle.

    B: Hip disorders with many osteoectomies, such as RAO, Charley, Salter.

    C: ACL and PCL reconstruction with arthroscopy

    D: Autologous chondrocyte in 3-D gel repair deep defect of knee cartilage

    E: Mesenchymal stem cell for un-union or delay-union of fracture

    F: Mesenchymal stem cell for aseptic necrosis of femoral head in early stage

    G: Mesenchymal stem cell for cartilage repair

2. Treatment of traumatic injury

3. Osteoporosis and Bone metabolic disorders

Research Activities:

1. Cartilage repair

    A: Autologous chondrocyte in 3-Dculture repair cartilage defect of rabbit knee

    B: Inducing of mesenchymal stem cells to osteoblast or chondrocyte.

    C: Proliferation and differentiation cytokines of Mesenchymal stem cells

    D: Long-life of chondrocyte and Mesenchymal stem cells

2. Bone biology, bone metabolism and osteoporosis

    A: Measurement method and repair mechanism of bone microdamage

    B: Effects of anti-resorptive agents on microdamage accumulation

    C: Measurement and evaluate the secondary mineralization under anti-resorptive agents

    D: Effects of anti-resorptive agents on the process of fracture healing, the interface of bone and implant, the stress shielding after THA.

    E: Effects of PTH on the process of fracture healing

    F: Effects of bisphosphonate on cartilage and bone in rheumatoid arthritis

    G: The role of subchondral bone in pathogenesis of osteoarthritis

3. Artificial prosthesis design and aseptic loosening

    A: Design and application of Hydroxyapaite-coated hip stem

    B: Design and application of hydroxyapatite-coated total hip prosthesis with terraced surface

    C: Mechanism and treatment of aseptic loosening of artificial implant

GRANTS:

1. 2004.8-2006.8: Grant for Scholar Coming Back from Foreign Country

2. 2000.10-2002.3: Eli Lilly Research Grant

   The effect of raloxifene, estrogen, and alendronate on fracture healing in ovariectomized rats.

3. 2002.4-2003.10: Ashahikasei Research Grant

   The effects of elcatonin and alendronate on fracture healing in monkeys.

4. 1997-1999: Young Investigator Grant of Peking University

   The role of cytokines in aseptic loosening of implants after total hip arthroplasty.

5. New Technique Grant of Chinese Hygienic Administration

   The development and application of biomaterials coating (hydroxyapatie) on hip implants.

AWARDS:

1.    2004 ICHTS/CSOS Travel Award (From Internal Chinese Hard Tissue Society). <Raloxifene, Estrogen, and Alendronate Affect the Processes of Fracture Repair Differently in Ovariectomized Rats>. The fourth Chinese Orthopedic Conference. 2004.09.22-26.Beijing.

2.    Travel Award <The effects of elcatonin and alendronate on the processes of
fracture healing in cynomolgus monkey>. The 1st Asia Pacific Bone Morphometry Conference. 2004.06.23-26. Takamastu, Japan

3.    Excellent Article Award.«The relationship of secondary mineralization and microdamage accumulation». The 20th Japanese Bone and Metabolism Conference.2002.7.25-27.Okiyama, Japan.

4.    Excellent Article Award.«Evaluation of secondary mineralization in dog rib». The 22th Japanese Bone Histomorphometry Conference.2002.6.27-29.Tokyo, Japan.

5.    Excellent Article Award “Suppressed Bone Turnover by 3 years YM-175 Treatment increases microdamage accumulation But does Not Reduce Bone mechanical strength” The 21th Japanese Society of Bone Morphometry, 2001, 6 23-27, Nogoya, Japan.

6.    Excellent Article Award “ Experimental studies on hydroxyapatite-coating hip implants” Chinese Society of Orthopedic Surgery. 1998, 7, Yan Tai, China.

7.    Excellent Teacher Awardby Peking University in 1997.

8.    Excellent Resident Award by Peking University in 1994.

9.    Guang Hua Scholarship Award by Peking University in 1993

10.    Excellent Student Award in 1985/1986, 1986/1987, 1987/1988, 1988/1989, 1989/1990 respectively by Bin Zhou Medical University

Books:

1. "Clinical Orthopedic Surgery" published in 1997, edited by Li Shimin and Dang Gengding Chapter 33    Treatment of Pelvic Fracture (Yongping Cao)

2. "Osteoarthritis" published in 2004,10, edited by Chen Baicheng
Chapter 4 Subchondral bone and osteoarthritis (Yongping Cao)
Chapter 6 Autologous chondrocyte and mesenchymal stem cell repair cartilage defect (Yongping Cao)

Publications:

1. Yongping Cao, Satoshi Mori, Tasuku Mashiba, Micheal S. Westmore, Linda Ma, Masahiko Sato, Tomoyuki Akiyama, Liping Shi, Satoshi Komatsubara, Kensaku Miyamoto, Hiromichi Norimatsu. Raloxifene, Estrogen, and Alendronate Affect the Processes of Fracture Repair Differently in Ovariectomized Rats. Journal of Bone and Mineral Research. 2002, 17(12): 2237-2246.

2. S.Mori, Y. Cao, K.Sogawa, K.Kondo, T.Sasaki, N.Hino, H.Yamashiro, M.Okada, K, Miyamoto, Y.Kawaguchi, T.Mashiba, H. Norimatsu. Enhanced _expression of protein phosphatase 2A associated with hyperphosphorylation of histone H1 in Alzheimer’s disease in brain. Research Communication in Molecular Pathology and Pharmacology 2003;113-114:67-73..

3. S. Mori, Y.Cao, T. Yamada, K. Sogawa, K. Kondo, N. Hino T. Miyazaki, Y.Kawaguchi, S. Oka, K.Kawasaki, T. Mashiba, H. Norimatsu. Enhanced _Expression of PP1?1, a Catalytic subunit isoform of protein phosphatase type1 and _expression of telomerase activity in Ewing’s Sarcoma. Research Communication in Molecular Pathology and Pharmacology 113:269-274, 2003.

4. Mashiba T, Mori S, Burr DB, Komatsubara S, Cao Y, Manabe T, Norimatsu H. The effects of suppressed bone remodeling by bisphosphonates on microdamage accumulation and degree of mineralization in the cortical bone of dog rib. J Bone Miner Metab. 2005;23 Suppl:36-42.

5. Akiyama T, Mori S, Mashiba T, Miyamoto K, Komatsubara S, Cao Y, Manabe T, Norimatsu H, Dobashi H, Tokuda M. Incadronate disodium inhibits joint destruction and periarticular bone loss only in the early phase of rat adjuvant-induced arthritis. J Bone Miner Metab. 2005;23(4):295-301.

6. Komatsubara S, Mori S, Mashiba T, Nonaka K, Seki A, Akiyama T, Miyamoto K, Cao Y, Manabe T, Norimatsu H. Human parathyroid hormone (1-34) accelerates the fracture healing process of woven to lamellar bone replacement and new cortical shell formation in rat femora. Bone. 2005 Apr;36(4):678-87.

7. Komatsubara S, Mori S, Mashiba T, Ito M, Li J, Kaji Y, Akiyama T, Miyamoto K, Cao Y, Kawanishi J, Norimatsu H. Long-term treatment of incadronate disodium accumulates microdamage but improves the trabecular bone microarchitecture in dog vertebra. J Bone Miner Res. 2003 Mar;18(3):512-20.

8. Komatsubara S, Mori S, Mashiba T, Li J, Nonaka K, Kaji Y, Akiyama T, Miyamoto K, Cao Y, Kawanishi J, Norimatsu H. Suppressed bone turnover by long-term bisphosphonate treatment accumulates microdamage but maintains intrinsic material properties in cortical bone of dog rib.J Bone Miner Res. 2004 Jun;19(6):999-1005. Epub 2004 Jan 19.

9. Eiji Yamada, Takashi Kusaka, Kensaku Miyamoto, Satoshi Tanaka, Shin Morita, Shouichi Tanaka, Yongping Cao, Satoshi Mori, Hiromichi Norimatsu, Susumu Itoh. Relationships between changes in Oxygenation during Exercise and Recovery in Trained Athletes. OPTICAL REVIEW. 2003, 10(5): 435-438.

10. Mashiba T, Mori S, Akiyama T, Cao Y, Kaji T, Komatsubara S, Miyamoto K, Manabe T, Norimatsu H. The relationship of spinal compress fracture and bone mineral density in osteoporosis patient. Journal of Japanese Bone Morphometry 2003, 12, 436-438. (in Japanese)

11. Chaoyang Li, Satoshi Mori, Yongping Cao, Jiliang Li, Yoshio Kaji, Tomoyuki Akiyama, Kensaku Miyamoto, Ken Iwata, Jun Kawanishi, Tasuku Mashiba and Hiromichi Norimatsu. Preadministration of Incadronate Disodium Prevents Cancellous Bone Loss in Proximal Tibia of Rats Induced by Ovariectomy at 8 weeks after withdrawal termination. Calcified tissue International. (In processing).

12. Yongping Cao, Satoshi Mori, Tasuku Mashiba, Satoshi Komatsubara, Yoshio Kaji, Tomoyuki Akiyama, Kensaku Miyamoto, Jun Kawanishi, Hiromichi Norimatsu. Both low dose and high dose elcatonin or alendronate delay callus remodeling, but not decrease mechanical strength of the weight-bearing fractured bone in cynomolgus monkey. Journal of Bone and Mineral Research. (In processing)

13. Yongping Cao, Tasuku Mashiba, Satoshi Mori, Yoshio Kaji, Tomoyuki Akiyama, Satoshi Komatsubara, Kensaku Miyamoto, Jun Kawanishi, Hiromichi Norimatsu. The Increased Degree of Secondary Mineralization in Basic Structure Units by Long-Term Bisphosphonate (Incadronate Disodium) Administration as Assessed by Scion Image Based on Contact Microradiography. Bone. (In processing).

14. Yongping Cao, Satoshi Mori, Tasuku Mashiba, Kensaku Miyamoto, Yoshio Kaji, Ken Iwada, Tomoyuki Akiyama, Jun Kawanishi, Hiromichi Norimatsu. The effects of ED-71 and Alendronate on the processes of fracture healing in rats. Journal of Bone and Mineral Research. (in Processing).

15. K. Miyamoto, S. Mori, S. Yamagami, F. Yongping Cao, Nakiri, S. Tanaka, T. Mashiba, Y. Kaji, J. Kawanishi, T. Akiyama, S. Komatsubara, K. Iwata, E. Yamada, H. Norimatsu. Kendo (Japanese fencing) players have side-to-side difference of calcaneal bone mass measured by Quantitative Ultrasound. Journal of Bone and Mineral Metabolism. (In Processing).

16. Yongping Cao, Shangcheng Yan. The experimental study on hydroxyapatite-coated hip implants. Chinese Journal of Orthopedics. 1997, 3:155-159.

17. Yongping Cao, Shangcheng Yan. Hydroxyapatite-coated hip arthroplasty. Chinese Journal of Orthopedics. 1997, 3:194-196.

18. Shangcheng Yan, Yu Yuan, Benming Xu, Yongping Cao. Clinical application of hydroxyapatite-coated femoral prosthesis. Chinese Journal of Orthopedics. 1997, 3:167-169.

19. Hongzhang Lu, Tianyue Zhu, Weibing Chai, Yongping Cao. Preliminary experimental studies of the alumina-coated prostheses. Chinese Journal of Orthopedics. 1997, 12:766-769.

20. Weibing Chai, Shu Neng Gao, Zhongtai Ma, Yongping Cao, Hong Zhang Lu. Prevention and treatment of knee arthroscopic complications analysis of 45 cases. Beijing Medicine. 1997, 2:76-79.

21. Licheng Wen, Zhongtai Ma, Yongping Cao, Li Cao, Weibing Chai, Shangcheng Yan. Bone Reaction of the Femur after Hip Arthroplasty with Cementless (radiological analysis of 34 hip joints). American Chinese Journal of Orthopedics, 1997, 3:8.

22. Licheng Wen, Zhongtai Ma, Yongping Cao, Li Cao, Weibing Chai, Shangcheng Yan. Clinical results of cementless total hip arthroplasty with Harris-galante prosthesis. Chinese Journal of Orthopedics. 1995, 6:73-75.

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