Lingsong Li, M.D., Ph.D., See Stem Cell Center, Beijing university

EDUCATION

1981-1986, M.D. Bethune University of Medical Science

1986-1989, M.S. Institute of Basic Medical Science, The Academy of Military Medical Science

1993-1999, Ph.D. Molecular and Cellular Biology Program
University of Washington

RESEARCH & CLINICAL EXPERIENCE

1990 - 1991 Visiting Scholar (Adviser: Robert Brashear)
Department of Neurology, University of Virginia
Pathogenesis of Stiff-Man Syndrome

1991 - 1993 Research Fellow (Adviser: Ake Lernmark)
Department of Medicine and Immunology, University of Washington
Molecular basis of autoimmune diabetes

1993 - 1999 Ph.D., (Adviser: Joseph Beavo)
Molecular and Cellular Biology Program, University of Washington
PDE VII function in T cells

1999-2000 Senior Research Fellow
Stanford University Medical Center,
T cell memory and stem cell development

2000-present Professor and Chairman: Departyment of Cell Biology and Genetics
Director: Peking University Stem Cell Research Center
Peking University Medical School

PUBLICATIONS

1. Linsong Li, William Hagopian, Robert Brashear and Ake Lernmark: Identification of autoantibody epitope of GAD in Stiff-man syndrome. J. Immunology 152: 930-934,1994

2. Wei Hao, Linsong Li, Ake Lernmark and Jerry Palmer: Functional state of the beta-cell affects expression of both forms of glutamic acid decarboxylase. Pancreas 9:558-562,1994

3. Linsong Li, Jianjie Jiang, William Hagopian, Denis Baskin and Ake Lernmark: Differential detection of rat islet and brain GAD isoforms with sequence-specific antibodies. J. Histochemistry Cytochemistry 43:53-59,1995

4. Ronald Dirkx, Annette Thomas, Linsong Li, Pietro De Camilli and Michele Solimena: Targeting of GAD67 to intracellular organelles is mediated by its interaction with the NH2-terminal region of GAD65. Journal of Biology Chemistry 270:2241-2246, 1995

5. Linsong Li, Cassian Yee and Joseph Beavo: CD3- and CD28-dependent induction of PDE7 required for T cell activation Science 283:848-851,1999

6. Yu Sun, Linsong Li, Fion Lau, Joseph A. Beavo and Edward A. Clark: Infection of CD4 Memory T cells by HIV-1 requires expression of phosphodiesterase-4. J. Immunology 165:1755-1761, 2000

7. Yiqin Du, Jing Chen, James L. Funderburgh, Xiuan Zhu, Lingsong Li. Functional Reconstruction of Rabbit Corneas by Human Limbal Cells Cultured on Amniotic Membrane. Molecular Version 9:635-43, 2003

8. Yun Bai, Qikuan Hu, Xiaoxia Li, Yajun Wang, Changsheng Lin, Li Shen, Linsong Li. Telomerase immortalization of human neural progenitor cells. NeuroReport15 (2)?245-49, 2004

9. Shaoheng Zhang, Ping Zhang, Jingxuan Guo, Zhuqing Jia, Chunyan, Zhou, Linsong Li. Enhanced cytoprotection and angiogenesis by bone marrow cell transplantation may contribute to improved ischemic myocardial function. The European Journal of Cardio-thoracic Surgery 25?188-95? 2004

10. Minjun YU, Zhifeng XIAO, Li SHEN and Lingsong LI. Mid-trimester fetal blood derived adherent cells share characteristics like mesenchymal stem cells but full term umbilical cord blood is not. British J. Haematology (accepted)

PRESENTATIONS AND POSTERS

1. Robert Brashear, Young Kim, Linsong Li and John Herr: Occurrence of antineuronal antibody without encephalomyeloneuritis in patients with paraneoplastic Lambert-Eaton syndrome. Annals of Neurology 30:310, 1991

2. Robert Brashear, Linsong Li and John Herr: Antineuronal antibody in two patients with paraneoplastic Opsoclonus-Ataxia. Neurology 42 (suppl 3): 457, 1992

3. Wei Hao, Linsong Li, Ake Lernmark and Jerry Palmer: T cell immunity to the GAD65 peptide fragment containing pyridoxal 5'-phosphate cofactor binding site sequence in IDDM patients. Autoimmunity 15:73, 1993

4. Handa K, White T, Li LS, and Hakomori S: P-selectin-dependent adhesion: requirement for expression of PSGL-1-like core protein and glycosylation. 9th International Congress of Immunology. San Francisco, CA, 1995

5. Linsong Li and Beavo JA: PDE7 function in T cell activation. Gordon Research Conference (Phosphodiesterase), Meriden, NH, 1998

6. Joseph J.Beavo and Linsong Li: A possible target for treatment of inflammatory diseases. The American Chemical Society 217:266, 1999

7. Lingsong Li: Stem cell research and the clinical application, The 6th Conference of Chinese Society for Hematologists, Dalian, China, 2000 (Invited Speaker)

8. Lingsong Li: The adult stem cell bank and its application, The 2000's Annual Meeting for Chinese Neuroscience Society, Beijing, China, 2001(Invited Speaker)

9. Lingsong Li: Building up an adult stem cell library for treatment of diseases, Shanghai 2001 Internation Forum for Bioengineering, Shanghai, China, 2001(Invited Speaker)

10. Lingsong Li: Transplantation of human stem cells for corneal disorders, The Eastern Forum of 2001, Shanghai, Shanghai, China, 2001(Invited Speaker)

11. Lingsong Li: 2002 Beijing International Symposium on Stem Cell Research (Chairman)

12. Lingsong Li: Treatment of neurological diseases by stem cell transplantation. Taipei International Stem Cell Forum 2002 (Invited speaker)

13. Lingsong Li: Oct4 (+) adult stem cells from multiple human tissues bear resemblance in both appearance and character. 2nd Annual Global Conference for Stem Cell Research. London, September 24-25, 2003 (Invited speaker)

14. Lingsong Li: The cellular basis for stem cell plasticity. 2nd NNI-NUS Neuroscience Symposium. Singapore, July 22-23, 2004 (Invited speaker)

AWARDS

The Chinese Yangzi River Scholar
Grants and Research Funding:
1. NIH Fellowship: HD07493 1999-2000
2. ?????????, ???????CMB???, 15??
3. ?????????????, 863???70??
4. ??????????????????????150??
5. ????????, ??????????50??
6. The National 973 project [2001CB510100], 2000??
7. The National 863 project [2001AA216171] , 120??
8. Beijing Ministry of Science and Technology [2002-489], 2000??
9. The National 863 project [2003AA216171] , 180??